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Biologische leeftijd berekenen

Biological Age By Dnam Phenoage

Biological Age By Dnam Phenoage Read More »

Aging is an inevitable process, but there are differences in susceptibility to age-related diseases and the risk of death among people of the same chronological age. This means that different people have differences in the rates of biological aging. To better understand the differences between biological and chronological age, it is necessary to measure biological aging. For this purpose, various calculators of biological age have been developed, which allow us to assess the impact of lifestyle on the aging process. One such biomarker is DNAm PhenoAge, a biological age biomarker developed at Yale University. DNAm PhenoAge significantly outperforms previous measurements in predicting various aging outcomes, including all-cause mortality, cancer, health span, physical functioning, and Alzheimer’s disease. This article was last reviewed by Svetlana Baloban, Healsens, on March 4, 2023. This article was last modified on 28 February 2023. What is Biological Age by DNAm PhenoAge? DNAm PhenoAge is an aging biomarker developed at Yale University that measures a person’s biological age. It is based on data from NHANES III and includes 9 biomarkers, such as the number of red and white blood cells, as well as a person’s chronological age. It is capable of predicting risks of various aging outcomes in tissues and cells and provides insight into important pathways of aging. The DNAm PhenoAge biomarker has been validated in NHANES IV as a strong predictor of morbidity and mortality risk, and has been tested for accuracy in calculations on several patient cohorts taking into account age-related outcomes. So, the biological age according to DNAm PhenoAge is a fairly accurate predictor of healthspan and lifespan at the epigenetic level. This means that biological age according to DNAm PhenoAge can be used as an indicator of a person’s health status before any pathologies appear. For most people, this can be a good indicator of the real state of their health before they encounter any diagnoses. IN THIS ARTICLE 1 What is Biological Age by DNAm PhenoAge? 2 How to use biological age calculator? 3 Is it possible to reverse biological aging? RELATED ARTICLES How to determine your biological age? To calculate biological age using DNAm PhenoAge, several simple blood tests need to be taken, including: Biological Age Blood Test Units Albumin ↑ Liver g/L Creatinine ↓ Kidney umol/L Glucose, serum ↓ Metabolic mmol/L C-reactive protein ↓ Inflammation mg/dL Lymphocyte percent ↑ Immune % Mean cell volume (MCV) ↓ Immune fL Red cell distribution width (RDW) ↓ Immune % Alkaline phosphatase ↓ Liver U/L White blood cell count (WBC) ↓ Immune 1000 cells/uL Age Years Table 1. Phenotypic aging measures In general, the DNAm PhenoAge biomarker can be determined through inexpensive blood tests, making it accessible to most people. After receiving the test results, online calculators can be used to calculate one’s biological age based on DNAm PhenoAge. This is convenient not only for a one-time calculation but also for monitoring the dynamics of biological age over time. Below you can see the biomarkers of our user who, over the course of several years, was able to reduce their biological age by 21 years compared to his chronological age with the help of changes in their diet and physical activity. Albumin Creatinine Glucose hs C-react Protein Lymphs (Lympocyte, % not absolute) MCV (Mean Cell Volume) RDW (Red Cell Dist Width) or Red Blood Cell Distribution Width (RDW-SD)? Alkaline Phosphatase WBC (White Blood Cells) Age ↑ ↓ ↓ ↓ ↑ ↓ ↓ ↓ ↓ 49 60.000 4.6 0.3 43.2 90 11.8 40 4.2 49.1 g/L umol/L mmol/L Ln(mg/L) % fL % U/L 10^3 cells/uL years Table 2. Lab test results of a 49-year-old man whose biological age is 21 years less than his chronological age. How to use biological age calculator? The calculated biological age by Levine’s DNAm PhenoAge is compared to the current chronological age. If the result is lower than your passport age, it is not only good news but also an indicator that your lifestyle positively affects your health. But what if the situation is the opposite? The most important thing is not to get upset! Now you know that you should pay attention to your health, and it makes sense to review your lifestyle. Thanks to the fact that there are several biomarkers, you can see what exactly to focus on. In addition, by making changes to your lifestyle, you can evaluate each individual indicator in addition to your biological age. To understand whether the dynamics are positive for each indicator, let’s return to Table 1. Each biomarker contains arrows ↓ or ↑. These arrows indicate a positive trend. For example, the downward arrow “↓” next to the glucose level indicates that lower levels of glucose indicate a younger biological age. Is it possible to reverse biological aging? New research shows that we can actually reverse biological aging through diet and lifestyle. In 2021, it was published the results of a pilot randomized clinical trial that demonstrated the ability to reverse biological age and was confirmed by objective outcomes. This is a very interesting observation, and there are several factors that can influence biological aging. Our lifestyle, comprising factors such as diet, physical activity, and stress, is considered a crucial element that affects biological age. In an effort to reverse the biological age in humans, researchers utilized a combination of diet, physical activity, and stress resilience techniques. The study monitored a group of individuals who were enrolled in a health program featuring a balanced low-calorie diet, daily 30-minute exercise at 60-80 percent intensity of maximum perceived exertion, and breathing exercises twice a day. Additionally, the study also focused on the quality of sleep, and it was discovered that insomnia was linked to an increase in DNAmAge clocks. Another study also found a connection between poor sleep quality/less sleep hours and accelerated aging in a small sample of 12 college female students. In the end, those who adhered to the recommended health program showed a reduction in age by 9 years, indicating that by maintaining a balanced diet, regular physical activity, and effective stress management,

Соотношение кортизол/ДГЭА-С

Cortisol/Dhea-S Ratio Of Longevity

Cortisol/Dhea-S Ratio Of Longevity Read More »

A complex interaction between cortisol and dehydroepiandrosterone-sulphate (DHEA-S) is crucial in the stress system balance. In particular, significantly higher or lower cortisol/DHEA(S) ratios have been associated with depression and aggression. In general, DHEA-S levels affect various body systems, as well as prevent aging (Chahal and Drake 2007). That is why the Cortisol DHEA ratio is a very informational indicator, which, along with other indicators calculated in Healsens, provides important information about human health. Thus, using the ratio of cortisol / DHEA-S, you can assess body responses to exercise or evaluate mental health. Another benefit is that you can check your cortisol and DHEA-S levels at home. This article was last reviewed by Svetlana Baloban, Healsens, on January 24, 2020. This article was last modified on 4 March 2021. How Cortisol and DHEA Sulfate Affect the Body Let’s start by looking at how cortisol and DHEA-S affect overall health. Dehydroepiandrosterone (DHEA) and cortisol are produced in the adrenal glands and are both derived from pregnenolone. So, DHEA and DHEA-S production reaches its peak at the age of 20–30 and then declines progressively with age. When it comes to cortisol levels, while some studies show that cortisol increases with age, others do not support this observation. However, everyone agrees that the reduction in DHEA-S entails disruption of various physiological systems. Stress Level As mentioned above, DHEA and DHEA-S play a protective role during acute stress as an antagonist to the action of the stress hormone cortisol. In turn, cortisol also helps to effectively manage stress. Let’s see how this happens. About 15 minutes after a stressful situation, cortisol levels rise and remain elevated for several hours. This marks the onset of stage 1. During this stage, there are elevations in cortisol with no corresponding changes in DHEA. Subsequently, glucose is mobilized, non-essential organ systems are suppressed, and inflammation is reduced. All of these physiological responses collectively enable the body to effectively cope with stress. However, in cases of chronic stress, this adaptive reaction can take a catastrophic turn: cortisol loses its ability to function normally. This transition ushers in stage 2. In this latter stage, the persistence of stress leads to a sustained peak in cortisol levels, matched by a corresponding elevation of DHEA. IN THIS ARTICLE 1 How Cortisol and DHEA Sulfate Affect the Body 2 Assessing Exercises 3 Adrenal/DHEA Restoration RELATED ARTICLES It becomes increasingly challenging to maintain appropriate blood sugar levels, to allow for adequate rest, to achieve high-quality sleep, and to achieve a harmonious balance among other hormones. This signals the arrival of stage 3, wherein stress persists and becomes chronic. During this stage, cortisol levels decrease, while DHEA remains elevated. In the absence of timely intervention, prolonged adrenal hyperstimulation can result in adrenal exhaustion. This condition is eventually manifested by a decline in both cortisol and DHEA, a phase often denoted as adrenal exhaustion or stage 4. Ultimately, this process may culminate in adrenal failure. Thus, the optimal ratio between salivary cortisol and DHEA is approximately 5:1 to 6:1, serving as an indicator of a normal state of adaptation to stress. When the body’s ability to maintain its normal stress adaptation is compromised, a process known as stress maladjustment can ensue. This phenomenon is now recognized as a chronic stress response, often identified by terms like pregnenolone steal, cortisol escape, or an elevated cortisol to DHEA ratio. The longer one remains in a state of chronic stress, the more pervasive its negative impact becomes on various aspects of physical well-being. As a result, individuals grappling with depression or heightened anxiety levels (measured at 0.24 ± 0.03 in the healthy group compared to 0.41 ± 0.12 in the group of individuals with severe anxiety), along with those dealing with post-traumatic stress disorder, exhibit disruptions in the cortisol to DHEA ratio. Nevertheless, it’s worth noting that certain studies have demonstrated the potential of DHEA treatment to mitigate the adverse health effects associated with stress. Musculoskeletal disorders We have already mentioned that cortisol dysfunction entails disorders of the musculoskeletal system. Thus, the higher the cortisol / DHEA-S ratio, the more serious the risk of this problem. Moreover, multiple regression analysis showed that the independent risk factor for sarcopenia was a serum cortisol/DHEA-S ratio ≥ 0.2. Sarcopenia is a type of muscle loss that occurs with aging and/or immobility. Immunity and Cortisol DHEA Ratio In addition, an increase in the cortisol / DHEA-S ratio with age (Phillips et al. 2007) is associated with immune dysfunction and the risk of infection in the elderly due to the fact that DHEA-S enhances immunity. However, cortisol has an inverse immunosuppressive effect (Buford and Willoughby 2005). It is also worth adding that DHEA-S is known for its antioxidant properties. Metabolic Syndrome Various studies have shown that both cortisol and DHEAS are related to metabolic syndrome, and type 2 diabetes. While high cortisol concentrations are associated with an increased risk of metabolic syndrome, high DHEA-S levels appear to be protective. By far, the strongest associations were observed for the cortisol / DHEA-S ratio. According to observations, the higher the coefficient, the greater the risk of metabolic syndrome. This ratio is also strongly associated with four of the five components of metabolic syndrome. Alzheimer’s Disease The cortisol / DHEA-S ratio may also be crucial in Alzheimer’s disease. For example, some studies have found a link between the cortisol / DHEA-C ratio and a decrease in hippocampal volume. It is worth saying that a decrease in the volume of the hippocampus is one of the early diagnostic signs of Alzheimer’s disease. This finding has been confirmed by other studies, observing the relationship between cortisol / DHEA-S and hippocampal atrophy (HA). For example, such a direct relationship was observed in patients with Cushing’s syndrome. Moreover, HC volume partially recovered following treatment-induced cortisol decrease. However, not all studies support this association within normal cortisol levels in healthy people. To sum up, the ratio of cortisol / DHEA sulfate can reflect: Assessing Exercises DHEA (Aldred et al. 2009; Cumming et al. 1986) and DHEA-S (Tremblay et al.

острый холецистит

WHAT IS CHOLECYSTITIS?

WHAT IS CHOLECYSTITIS? Read More »

Calculous cholecystitis as well as acalculous cholecystitis is described as inflammation of the gallbladder. This common intra-abdominal infection can generate severe complications due to its natural history and requires operative treatment. What are the causes of this disease? In this article, we’ll talk about what cholecystitis is, discuss the risks of this problem and take a look at the most effective treatment options. This article was last reviewed by Svetlana Baloban, Healsens, on January 4, 2021. This article was last modified on 7 February 2021. What is Cholecystitis? Etiology As stated above, the problem comes from the cystic duct blockage, which causes inflammation. Normally, bile is made in the liver, travels down the bile duct, and is stored in the gallbladder. After eating certain foods, especially spicy or greasy foods, the gallbladder is stimulated to release the bile from the gallbladder through the cystic duct, down the bile duct into the duodenum. This process aids in food digestion. The gallbladder not only stores the bile, but it can concentrate it as well. Concentrated bile is susceptible to precipitation forming stones when homeostasis is disrupted. It can occur due to bile stasis, supersaturation of cholesterol and lipids from the liver, disruption in the concentration process, and cholesterol crystal nucleation. IN THIS ARTICLE 1 What is Cholecystitis? Etiology 2 Risks of Gallbladder Disease 3 Acute Cholecystitis Treatment 4 Timing Of Surgical Removal of the Gallbladder RELATED ARTICLES When cystic duct blockage is caused by a stone, it is called acute calculous cholecystitis. So, about 95% of people with acute cholecystitis have gallstones. It is worth knowing that temporary obstruction by gallstones can cause pain, the process is called biliary colic. The diagnosis of biliary colic is upgraded to acute calculous cholecystitis if the pain does not resolve in six hours. If no stone is identified, it is called acuteacalculous cholecystitis. Regardless of the cause of the blockage, the gallbladder wall edema will eventually cause wall ischemia and become gangrenous. The gangrenous gallbladder can become infected by gas-forming organisms, causing acute emphysematous cholecystitis. The main thing to know is that all of these conditions can quickly become life-threatening. Moreover, the gap has the highest mortality rate. In addition to an acute condition, cholecystitis can also be chronic. Risks of Gallbladder Disease The risk of gallbladder disease increases in women, obese patients, pregnant women, and patients in their 40s. Drastic weight loss or acute illnesses may also increase the risk. The formation of gallstones and this condition can run in families. What is more, genetic factors are estimated to account for only approximately 25% of the overall risk of gallstones. Other conditions that cause the breakdown of blood cells, for example, sickle cell disease, also increase the incidence of gallstones. Acute Cholecystitis Treatment Cases of acute untreated cholecystitis could lead to perforation of the gallbladder, sepsis, and death. Cholecystitis is a condition best treated with surgery. However, it can be treated conservatively if necessary. Surgery to remove the gallbladder or cholecystectomy is the best treatment! There are low morbidity and mortality rates with quick recovery. This can also be done with an open technique in cases where the patient is not a good laparoscopic candidate. In situations in which the patient is acutely ill and considered a poor surgical candidate, he or she may be treated with temporizing percutaneous drainage of the gallbladder. Milder cases of chronic cholecystitis in patients considered poor surgical candidates might be managed with low-fat and low-spice diets. The results of this treatment vary. Medical treatment of gallstones with ursodiol is also reported to have occasional success. In addition, the doctor may prescribe antimicrobial agents. They are meant for high-risk patients, especially those having gallbladder necrosis. The use of broad-spectrum antibiotics and sometimes antifungal agents is associated with better prognosis. Timing Of Surgical Removal of the Gallbladder A 2010 meta-analysis compared early laparoscopic cholecystectomy (ELC – 1 wk of onset of symptoms) and delayed laparoscopic cholecystectomy (DLC – at least 6 wk after symptoms free). The researchers concluded that similar results were obtained in both cases with respect to bile duct injury. However, hospital stay was shorter for the early laparoscopic cholecystectomy group. The results also showed that the group where surgery was not delayed had lower mortality; bile duct complications and improvement in many other parameters were analyzed.

Kirtan Kriya

Discover The Benefits Of Kirtan Kriya For Stress Reduction

Discover The Benefits Of Kirtan Kriya For Stress Reduction Read More »

A growing number of medical studies confirm that Kirtan Kriya (KK) meditation is not only a stress management tool, but can also aid in the treatment of cognitive impairment, memory improvement and, as a result, it plays a role in Alzheimer’s Disease Prevention. KK has also been proven to improve sleep, reduce depression, reduce anxiety, activate immune system genes, and even increase telomerase. Therefore, it is obvious that we paid our attention to Kirtan Kriya benefits for a reason, since it has already passed a rigorous randomized controlled trial (RCT) design. So, its effectiveness has been confirmed experimentally. We will start by telling you more about the research carried out. Hopefully, after reading this, some of you will make this wonderful practice a part of your healthcare plan. This article was last reviewed by Svetlana Baloban, Healsens, on January 24, 2020. This article was last modified on 7 March 2021. Cognitive Function and Memory Improvement There are many studies proving that yoga practices are increasingly shown to be effective for the treatment of age-related cognitive issues. Let us start with a 2017 12-week study that tested the effects of kundalini yoga training on mild cognitive impairment (MCI). What makes this study interesting is that the results of yoga practice were compared with the results of training to improve memory MET. MET was developed by researchers within the UCLA Longevity Center. It is well studied and has become a gold standard intervention for cognitive training. At the same time, improvement in memory with MET training is observed in both healthy people and people with cognitive problems. Thus, MET provides a rigorous control for KY meditation. It also needs to be noted, that cognitive decline is a strong predictor of Alzheimer’s disease leading to dementia. Overall, the study provides evidence of the benefits of Kundalini yoga, including Kirtan Kriya, for improving cognitive function in individuals with MCI The Design Research The trial participants were gathered among the people ≥55 y.o. with a mild cognitive impairment. To assess the impact of training, 2 different groups were created. So, part of the people randomly got into a 12-week program on kundalini yoga (KK). All others were involved in the MET memory improvement training, which we wrote about above. IN THIS ARTICLE 1 Cognitive Function and Memory Improvement 2 Kirtan Kriya Helps to Improve Mood 3 Better Sleep 4 Influence at Telomere Length and Activity 5 As alternative Treatments for Depression 6 How to do Kirtan Kriya Practice RELATED ARTICLES In addition, all program participants were administered extensive tests assessing their cognitive abilities. Researchers assessed their verbal and visual memories, visual-spatial skills, individual executive, and executive functions. People were also tested for depression, present symptoms of apathy, and psychological resilience to stress. You can also take these tests by downloading👇 the app. The participants of the experiment passed such testing several times. The tests were passed at baseline (pre-intervention) and repeated at 12 and 24 week post-intervention. Let’s say a few more words about what exercises were performed in the yoga group. First, once a week the participants would hook up for a 60-minute kundalini lesson. In addition, all participants were required to do a 12-minute Kirtan Kriya meditation daily. Results As a result of the experiment, both groups had significant improvement in memory. However, the yoga team additionally showed a broader effect on executive functioning, with greater improving in their mood. In addition, such positive dynamics persisted after the end of the training. Impressive, isn’t it? A similar RCT was conducted in 2016. Here the results of the meditation group were compared with the machine learning program. The researchers came up with the same result. Kirtan Kriya meditation can help people with early memory loss. It is worth mentioning that the participants practiced the 12 minutes kirtan kriya meditation only. And this is only 12 minutes a day at home and at a convenient time. » Learn more about how blood tests can reveal the extent of cumulative stress on your body. Cerebral Blood Flow Changes Interestingly, Kirtan Kriya benefits also showed cerebral blood flow changes during the practice of KK. Thus, there was observed a significant increase in cerebral blood flow (CBF) within the frontal lobe and right superior parietal lobe. Moreover, the posterior cingulate gyrus (PCG) is also activated. All this suggests that such activation of the brain with increased blood flow may have a beneficial effect or provide protection against neurodegeneration. However, a larger study is needed to confirm this conclusion. And finally, Luders’s study concluded that someone who practices meditation regularly, has a 7.5 years younger brain.The age was calculated as BrainAGE index. It was also found that with every passing year, meditators’ age reduced. Thus, the researchers concluded that Kirtan Kriya benefits help maintain the brain and its activity in good shape. Kirtan Kriya Helps to Improve Mood Various studies have shown that Kirtan Kriya markedly improves mood, reduces anxiety, tension, and fatigue. There was also a significant improvement in depressive symptoms and mental health. And this effect was observed both in healthy people, so in people with memory loss. It is worth mentioning that the latter participated in the 8-week Kirtan Kriya meditation program, which highlights Kirtan Kriya benefits. Studies have also shown that 8 weeks of KK helped in alleviating worry and soaring positive mood and energy. In addition, a majority of patients found the sessions relaxing, calming, peaceful, and uplifting, demonstrating the multiple Kirtan Kriya benefits. Better Sleep In the same way, sleep disruption has negative effects on health, performance, and quality of life. It is also known to impair cognitive function in healthy people, to accelerate cognitive decline, and to predict incident MCI and dementia. In addition, sleep disturbances can generate glucose intolerance, obesity, and hypertension. And finally, sleep impairment has likewise been linked to increased risk for type 2 diabetes and some other diseases. That being said, research shows that an 18-week 12-minute daily meditation program may be effective in reducing stress and improving sleep and mood. Influence at

КАК СТРЕСС ВЛИЯЕТ НА ЗДОРОВЬЕ

HOW STRESS AFFECTS THE BODY

HOW STRESS AFFECTS THE BODY Read More »

Today’s life rhythms and demands are often complex and require intense physical and psychological efforts. Generally, acute stress reactions in young healthy individuals do not cause any harm to their health. However, if the threat is not eliminated, such stimuli that exceed a specific person’s ability to adapt can cause significant damage. But how dangerous is such harm and how exactly does stress affect the body? Positive and negative stress As mentioned earlier, not all stress has a negative effect. When the body experiences stress and uses it to overcome lethargy or increase productivity, stress becomes positive and healthy . This type of stress is also known as eustress. Therefore, stress is positive when it prompts us to adapt and thus enhances our adaptive mechanisms. This stimulating effect of stress gives athletes a competitive edge and speakers enthusiasm. Stress is negative when it exceeds our ability to cope with it. Such stress exhausts the body’s systems and leads to behavioral or physical problems. This harmful stress is called distress. If an event triggers an excessive reaction, confusion, poor concentration, and anxiety, it leads to a decrease in productivity. . IN THIS ARTICLE 1 Positive and negative stress 2 Depression 3 How stress affects health? RELATED ARTICLES Fortunately, under normal circumstances, within three minutes after the threatening situation disappears and the real or perceived danger is eliminated, the “fight or flight” response subsides. During this time, our body relaxes and returns to its normal state. Heart rate, blood pressure, respiration, muscle tension, digestion, metabolism, and the immune system all return to normal. However, if stress persists after the initial “fight or flight” response, the body’s reaction enters the second stage. At this stage, the activity of the sympathetic nervous system decreases, and adrenaline secretion decreases, but the secretion of corticosteroids (such as cortisol) remains elevated, exceeding normal levels. Finally, if stress continues and the body cannot cope with it, an organism’s energy levels are likely to decline, leading to a state of exhaustion. Depression sets in. Depression When it comes to depression, it is defined as experiencing 5 or more of the listed symptoms persistently for 2 or more weeks, causing significant emotional distress. We have already discussed depression and its diagnosis in the article “Depression Screening | Anxiety and Depression.” Currently, depression is one of the most common mental disorders worldwide. It is estimated that 350 million people globally suffer from some form of depression . It is also the leading cause of disability worldwide. Additionally, it is the most costly mental disorder, accounting for 33% of all brain-related disease costs in Europe. This corresponds to 1% of the entire European economy (GDP) . According to the estimates of the Centers for Disease Control and Prevention in the United States, stress accounts for approximately 75% of all doctor visits . Patients often come with complaints such as: But can stress cause serious harm to health? How stress affects health? Hypertension and Atherosclerosis When it comes to how stress affects health, it can confidently be stated that prolonged negative stress can damage almost all organs and tissues. For example, chronic stress leads to sustained elevation of blood pressure and vascular hypertrophy . This means that the muscles that constrict the blood vessels thicken, causing increased blood pressure. Additionally, there is a tendency to respond to all types of stress with a vascular reaction. In turn, chronically elevated blood pressure forces the heart to work harder, leading to left ventricular hypertrophy. Over time, this condition can damage arteries and lead to the formation of plaques (atherosclerosis). And this is just one of the many chains of influence of chronic stress on health. How stress affects the body: Immunity and chronic inflammation Elevated levels of stress hormones associated with chronic stress also suppress the immune system, directly influencing cytokine profiles . Cytokines are communicative molecules primarily produced by immune cells (see Roitt et al., 1998). In response to a higher number of chronic stressors, pro-inflammatory cytokines disrupt regulation and lead to immune suppression. As a result, this leads to slower wound healing, weaker antibody response to vaccination, and decreased ability to fight viral infections. This means that psychological stress can actually induce an acute-phase response typically associated with infections and tissue damage. Such immune imbalance results in a state of low-grade chronic inflammation, which, in turn, can serve as a precursor to the development of other diseases. Diseases associated with both stress and inflammation include: Chronic stress is particularly dangerous for elderly individuals. Impact on the brain Chronic stress has been shown to be associated with macroscopic changes in specific brain regions. For example, significant reduction in gray matter has been observed in individuals suffering from prolonged occupational stress . However, our understanding of the molecular pathways underlying these changes is still in the early stages of research. It is worth noting that physical exercise can support brain health in counteracting stress-related depression. This can manifest as overall improvement in cognitive abilities, reduced risk of neurodegenerative diseases, and alleviation of depression. How stress affects the body: Gastrointestinal disorders It is known that stress has a significant impact on gastrointestinal disorders such as peptic ulcer disease (PUD) and ulcerative colitis (UC). Specific stressful life events are closely associated with the onset or exacerbation of symptoms in other common chronic digestive system disorders, including: Functional gastrointestinal disorders Inflammatory bowel diseases (IBD) Gastroesophageal reflux disease (GERD). Furthermore, early-life stress in the form of abuse or trauma also plays an important role in predisposing individuals to the development of gastrointestinal disorders and IBD later in life. How stress affects the body: Impact on genetic health Finally, a recent study on stress conducted by Epel and Blackburn demonstrates that stress has a pronounced negative impact on genetic health by reducing the level of telomerase, an enzyme responsible for maintaining the length of telomeres, protective caps of DNA. Shorter telomeres are associated with inflammation, accelerated aging, and Alzheimer’s disease. Furthermore, the study revealed that individuals who experienced childhood

cardiovascular risk assessment

CARDIOVASCULAR RISK ASSESSMENT

CARDIOVASCULAR RISK ASSESSMENT Read More »

Cardiovascular diseases such as ischemic heart disease, thrombosis, arterial hypertension with its complications – myocardial infarction and stroke – constitute a dynamic multistep process that is closely related to inflammation. It is well-known that CVD diseases rank first among all other diseases of mankind. Traditionally for making an accurate diagnosis, the patient must undergo a series of procedures, undergo lab tests so that the doctor can prescribe the necessary treatment. However, there is another way. Doctors can use cardiovascular risk assessment tools aimed at detecting the disease at an early stage. This time, not only will we consider different methods / risk calculators that are now used in clinical practice, but we will also make the corresponding calculations using a real example of a patient’s history. And, of course, let’s talk about why, given the presence of such intelligent systems, the CVD problem is still relevant. This article was last reviewed by Svetlana Baloban, Healsens, on January 24, 2020. This article was last modified on December 15, 2020. Why do you need cardiovascular risk assessments? Before proceeding to describe various calculation methods, let’s find out why they are needed at all. To begin with, we shall that most heart diseases develop completely asymptomatically over many years. In practice, it means that if one doesn’t feel any health problems, he or she simply does not go to the doctor unless a critical condition occurs. So, according to some estimates, 3.7 million Americans remain with undiagnosed heart disease. At the same time, the highest proportion of undiagnosed CVDs, which led to death from cardiovascular diseases, is among people aged 18–59 years. This is especially true when you consider that obesity, type 2 diabetes, and other risk factors are becoming more common at a young age. Second, understanding the risks allows for early diagnosis of CVD and, accordingly, preventive lifestyle interventions or treatment as needed. And thirdly, the assessment of risk factors can clearly demonstrate how the total risk changes if you switch to a healthier lifestyle. That is why, as early as in 1948, the Framingham Heart Study was initiated under the direction of the US National Heart, Lung, and Blood Institute. It was an ambitious medical research project that changed the medicine we know. As part of this study, the main risk factors for cardiovascular disease were identified. These include the following indicators: IN THIS ARTICLE 1 Why do you need cardiovascular risk assessments? 2 SCORE Risk Chart (Systematic Coronary Risk Evaluation) 3 Framingham Risk Score 4 Reynolds Risk Score 5 ASCVD (Atherosclerotic Cardiovascular Disease) Risk Score 6 PROCAM Score (Prospective Cardiovascular Munster Study) 7 QRISK (QRESEARCH Cardiovascular Risk Algorithm) 8 The 65yo Patient’s CVD Risks 9 Effectiveness of Using CVD Risk Scoring RELATED ARTICLES Valuable information has also been obtained on the role of cholesterol, age, gender, and psychological problems. During this time, the risk assessment has changed and developed significantly. In this article, we will analyze what cardiovascular risk assessment means and what calculators are used now in medical practice. SCORE Risk Chart (Systematic Coronary Risk Evaluation) The European guidelines for cardiovascular disease (CVD) prevention recommend the use of modified SCORE risk charts. SCORE estimates the 10-year risk of fatal and non-fatal CVDs such as myocardial infarction, cerebrovascular disease, and congestive heart failure. The first Joint Working Group of European societies on coronary prevention used a simple risk chart. For their calculations, they considered the following categories: Then, the diagram became more complex in order to assess risks more accurately. So, in addition to total cholesterol, the ratio of cholesterol to HDL cholesterol was also taken into account in risk assessments. In addition, given the geographic variability in cardiovascular risk across Europe, two SCORE charts have been developed for countries with high and low CVD risk. Countries with low risk include countries such as Andorra, Austria, Belgium, Cyprus, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Israel, Italy, Luxembourg, Malta, Monaco, Netherlands, Norway, Portugal, San Marino , Slovenia, Spain, Sweden, Switzerland and the United Kingdom of Great Britain and Northern Ireland. Countries at high risk of CVD: Bosnia and Herzegovina, Croatia, Czech Republic, Estonia, Hungary, Lithuania, Montenegro, Morocco, Poland, Romania, Serbia, Slovakia, Tunisia and Turkey. And the group of countries with a very high risk (note that the diagrams may underestimate the risk in these countries) included such countries as: Albania, Algeria, Armenia, Azerbaijan, Belarus, Bulgaria, Egypt, Georgia, Kazakhstan, Kyrgyzstan, Latvia, North Macedonia , Moldova, Russian Federation, Syrian Arab Republic, Tajikistan, Turkmenistan, Ukraine and Uzbekistan. Due to this SCORE scale, the following cardiovascular diseases can be detected: stroke, myocardial infarction, pulmonary embolism, dissecting aortic aneurysm. Framingham Risk Score The Framingham Risk Scale (FRS) determines the presence of diseases such as angina pectoris, coronary heart disease, myocardial infarction, stroke. Like the SCORE scale, this system opens the door for making a forecast for the next 10 years. This scale was developed in North America. Thus, NCEP 4 recommends the Framingham Risk Score for cardiovascular risk assessment. You can also calculate it by yourself. The total risk on the Framingham scale is defined as: A value over 30% indicates a very high risk of cardiovascular disease. A 10-year risk estimate can be obtained as a percentage, which is then used to make decisions about disease prevention. This assessment is also evolving. For example, in 2009 CCS added additional risks to the Framingham risk scale. It included a family history of coronary heart disease in a first-line relative. It takes into account male first-degree relative younger than 55 years and female first-degree relative younger than 65 years old. For elderly patients, sensitive C-reactive protein results can also help to reclassify risks. Reynolds Risk Score If you are healthy and do not have diabetes, the Reynolds Risk Score is designed for your cardiovascular risk assessment. It may predict your risk of heart attack, stroke, or other serious heart diseases over the next 10 years. The risk calculation is designed for people aged 45 and over. The scale assesses the following risk factors: gender, age, systolic blood pressure, total and

Treatment For Vitamin D Deficiency

Treatment For Vitamin D Deficiency Read More »

Understanding the importance of vitamin D for health at any age is crucial. Since low levels of vitamin D are common, it is important to know how to treat it. We will discuss various ways to improve health through sunlight exposure, proper nutrition, and the use of vitamin D supplements as part of the treatment for vitamin D deficiency. Additionally, we will explore how individual characteristics can influence the success of achieving healthy vitamin D levels, as well as determine safe dosages for its maintenance. This article was last reviewed by Svetlana Baloban, Healsens, on October 24, 2020. This article was last modified on 29 October 2020. Let us start with how we define vitamin D deficiency. In summary, a deficiency occurs when the serum 25-hydroxyvitamin D level is less than 20 ng/ml (50 nmol/L). If your serum 25-hydroxyvitamin D level is between 20 and 30 ng/ml (50 to 75 nmol/liter), then we are talking about vitamin D insufficiency. Values of less than 10 ng/ml refer to severe vitamin D deficiency. We will analyze the approach to treat this deficiency separately. Treatment for vitamin D deficiency Sunbathing Sunbathing, mentioned in the article about the influence of vitamin D on health, is an excellent way to compensate for vitamin D deficiency. Sunlight (ultraviolet) promotes the formation of about a dozen beneficial compounds, including not only vitamin D but also nitric oxide (NO5), which is beneficial for reducing blood pressure, cardiovascular diseases, and metabolic syndrome. The skin contains significant reserves of nitric oxide, which, when exposed to ultraviolet light, can be converted into NO and enter the systemic circulation. Studies on humans show that this process can cause dilation of arterial vessels and reduction in blood pressure. IN THIS ARTICLE 1 Treatment for vitamin D deficiency 2 Vitamin D Deficiency Treatment Using Supplements 3 Maintenance Dose of Vitamin D 4 Monitoring Vitamin D Levels RELATED ARTICLES It is also noted that the impact of ultraviolet radiation can suppress clinical symptoms of multiple sclerosis independently of vitamin D synthesis . Sunlight is also beneficial for maintaining healthy erectile function. However, it is worth remembering that UV radiation remains a proven carcinogen. What to do in this situation? It is recommended to consider the option of “healthy sun exposure”, when you are in the sun during the safest times – before 10 in the morning and after 4 in the evening. It is important to remember that sunscreen with a sun protection factor of 30 can reduce vitamin D synthesis in the skin. Additionally, people with naturally dark skin have built-in sun protection and require at least three to five times longer exposure to produce the same amount of vitamin D. Choose the safest times for sunbathing without sunscreen. Food Another way to increase the level of vitamin D in the body is through the consumption of food products. Very few foods naturally contain or are enriched with vitamin D. However, in combination with sunbathing, food products can also be beneficial. Pay attention to foods such as fatty fish (salmon, mackerel, tuna), egg yolks, cheese, liver, and vitamin D-fortified dairy products and cereals – they can become a good source of this vitamin. In addition to sunbathing, in case of vitamin D deficiency (especially at critical levels when the level of 25(OH)D is less than 20 ng/ml), it is advisable to take vitamin D in the form of supplements. It is worth noting that the increase in the level of 25(OH)D when taking vitamin D supplements is highly individual. In the next chapter, we will delve into the issue of vitamin D dosages through supplements recommended at present. Vitamin D Deficiency Treatment Using Supplements Vitamin D deficiency is defined when the level of 25(OH)D is below 20 ng/mL. It is important to realize that unprotected sun exposure is the primary source of vitamin D for both children and adults. Vitamin D synthesized in the skin can remain in the blood at least twice as long as vitamin D obtained from external sources. However, if opportunities for sunbathing are unavailable, considering vitamin D supplementation becomes advisable. The amount of vitamin D needed to treat deficiency largely depends on the degree of deficiency and key risk factors. Let’s delve into clinical recommendations for treating vitamin D deficiency using supplements. Research findings indicate a rate of increase in the level of 25(OH)D in serum of approximately 0.4 ng/mL/μg/day. This means that intake of 100 IU/day of vitamin D increases the level of 25(OH)D in serum by less than 1 ng/mL. For instance, if your level of 25(OH)D in serum is 15 ng/mL, an additional daily intake of about 1500 IU of vitamin D2 or vitamin D3 is required to achieve and maintain a level of 30 ng/mL. However, to achieve a similar increase in the level of 25(OH)D in serum among individuals with obesity, two to three times more vitamin D is required. Vitamin D can be taken on an empty stomach or with meals, and dietary fats are not required. Taken three times a year, weekly, or daily, vitamin D can be effective in maintaining the level of 25(OH)D in serum for both children and adults. » Discover everything about what your cholesterol results mean. How much vitamin D should I take if I’m deficient? So, the amount of vitamin D needed to treat a deficiency depends largely on the degree of the deficiency and the underlying risk factors. Initial supplementation with Vitamin D3 for 8 weeks, either 6,000 IU daily or 50,000 IU weekly, can be considered. When the vitamin level exceeds 30 ng/ml, the daily maintenance dose will be 1500 to 2000 IU. If after 8 weeks your level of 25(OH)D in the blood has not increased, it is recommended to undergo testing for celiac disease or hidden cystic fibrosis. Higher-risk adults may require higher starting doses of vitamin D3. These people include African Americans, Hispanics, people with obesity, chronic illness, and taking certain medications. Typically, your doctor may prescribe 10,000 IU of vitamin per day. For such people,

thyroid gland hormones

Thyroid Gland Hormones

Thyroid Gland Hormones Read More »

All hormones in our body must work in concert to maintain optimal health. Thyroid gland hormones play a major role in regulating this work. In today’s article, we will discuss which symptoms can tell us that not everything is in order with our thyroid hormones. We will also take a closer look at the three ways to check the functioning of the thyroid gland. This article was last reviewed by Svetlana Baloban, Healsens, on January 24, 2020. This article was last modified on 17 February 2020. If we look into history, we will see that thyroidology itself (the study of the thyroid gland) is a relatively new field of endocrinology. In spite of this fact, however, as early as in 1600 BC Chinese writers described the treatment of thyroid goiter (an enlarged thyroid gland) with burnt seaweed. However, the goiter itself was not specifically associated with the thyroid gland. It was only in 1656 that Thomas Wharton first gave the thyroid the name that is still in use today. How thyroid gland hormones affect health Thyroid hormone is the main regulator of hormonal levels. Many people do not realize that they have a dysfunction of the thyroid gland even though it is a disorder, every tenth of which, leads to many adverse health changes. In this case we are talking about already diagnosed problems. However, according to the American Thyroid Association, up to 60 percent of people with thyroid disease go undiagnosed. And an undiagnosed illness can put patients at risk of getting some serious illnesses. How do thyroid hormones affect our body? IN THIS ARTICLE 1 How thyroid gland hormones affect health 2 Thyroid stimulating hormone (TSH) 3 Triiodothyronine (T3) 4 Thyroxine (T4) 5 The role of the pituitary gland RELATED ARTICLES Heart Thyroid gland hormones have a permissive effect on catecholamines. Catecholamines are a group of similar hormones produced by the adrenal medulla. Those, in turn, increase the expression of beta-receptors to increase heart rate, stroke volume, cardiac output, and contractility. Often, people with hypothyroidism have very high cholesterol levels (350 and higher), and a bunch of other risk factors leading to a cardiovascular disease. Thermoregulation Thyroid hormones are responsible for thermoregulation, which is why people with reduced thyroid function (hypothyroidism) often complain that they are constantly cold. This happens due to increased available energy in the body, as well as increased appetite, heart rate, and the amount of oxygen delivered to various parts of the body. Metabolism These hormones also help control the basal metabolic rate (the rate at which calories are burned). So fatigue and excess weight are also signs of hypothyroidism. On average, an underactive thyroid gland can add 5 to 15 kg of weight. But most of that extra weight will come from water and salt. In addition, decreased thyroid function can cause constipation, memory problems, and lethargy. An overactive thyroid gland (hyperthyroidism) is characterized by the opposite signs: having difficulty gaining weight, feeling hot, having frequent bowel movements, feeling nervous, and having a rapid heart rate. Other functions controlled by thyroid hormones include metabolism of fats, proteins and carbohydrates, as well as protein synthesis. Relation to other hormones There is also an interrealtion between thyroid function and control over other hormone levels. So, deviation of the thyroid hormone level from the norm can adversely affect the work of the adrenal glands. For instance, сertain human autoimmune conditions can destroy both the thyroid gland and adrenal cortex resulting in combined hormone deficiencies. Moreover, dysfunction of the thyroid gland negatively affects the levels of sex hormones. Hyper- and hypothyroid men have increased rates of sexual dysfunction, including erectile dysfunction (ED). But the good news is that treatment of thyroid disorder at least partially reverses sexual dysfunction. Thyroid hormone also affects fertility, ovulation, and menstruation. What hormones does the thyroid gland produce? In the following, we will discuss three tests for testing thyroid function – thyroid stimulating hormone (TSH), free T3, and free T4. You will probably want to make these tests part of your early diagnosis program and get them done regularly. Thyroid stimulating hormone (TSH) Thyroid stimulating hormone is a hormone that stimulates the thyroid gland. It is also known as TSH and is a glycoprotein hormone produced by the anterior pituitary gland. It is the main stimulus for the production of thyroid hormones. The TSH screening test is the first line test for suspected thyroid disease. According to the American Thyroid Association, TSH levels are typically between 0.4 and 4.0 milliunits per liter (mU / L). However, these ranges will vary among laboratories and the upper limit can be raised from 4 to 5. If your level is higher than this, you are most likely to have an underactive thyroid gland. However, some studies show that this range should actually lie within 0.45–2.5 mIU / L. This is because TSH below the upper limit of the normal reference range poses an additional risk of progression to overt hypothyroidism over time. So, high TSH levels indicate that your thyroid gland is not producing enough thyroid hormones. This condition is called hypothyroidism, which we wrote about above. Low TSH levels, on the other hand, may mean that your thyroid is producing too much hormone, the condition is called hyperthyroidism. Hyperthyroidism can be caused by Graves’ disease. This is a condition when your body’s immune system attacks the thyroid gland. It can also be a result of too much iodine in your body. T3 (triiodothyronine) and T4 (thyroxine) T3 (triiodothyronine) and T4 (thyroxine) are the two key thyroid hormones that are produced by the thyroid gland. The main product of thyroid secretion is T4, while T3 is secreted only in small amounts. However, the activity of T3 is three to four times higher than that of T4. Nonetheless, both hormones play a vital role. Both T3 and T4 contain iodine. And it is iodine that is one of the main building blocks of both hormones. So let’s talk about tests that help measure the content of these hormones in the body.

Most common digestive disorders

MOST COMMON DIGESTIVE DISORDERS: PART 2

MOST COMMON DIGESTIVE DISORDERS: PART 2 Read More »

So, we continue to consider the most common digestive disorders. Last time, we used vitamin B12 deficiency and improper chewing. We also discussed what steps need to be taken in case of lactose intolerance and why the bacterium called Helicobacter pylori is dangerous. Today we will continue to talk about the most common digestive disorders. This article was last reviewed by Svetlana Baloban, Healsens, on 16 October 2020. This article was last modified on 15 October 2020. Hypochlorhydria A more common and often overlooked digestive disorder is hypochlorhydria. Achlorhydria or hypochlorhydria is a condition when hydrochloric acid production is absent or reduced. It is usually secondary to an underlying medical condition. So, hypochlorhydria can lead to insufficient food dissolution, and therefore to impaired absorption of nutrients. Elderly people often suffer from hypochlorhydria. Its symptoms are often confused with symptoms of another disorder – high acidity, or gastroesophageal reflux disease (GERD). The result of this confusion is the use of antacids, which only makes the disease worse. When achlorhydria is suspected, multiple tests are conducted to confirm the diagnosis and to find its primary cause: IN THIS ARTICLE 1 Hypochlorhydria 2 Leaky Gut Syndrome (LEPS) 3 Irritable bowel syndrome This condition can also be detected by determining the mineral composition of the hair. Leaky Gut Syndrome (LEPS) Furthermore, let’s talk about leaky gut, although this disorder causes some controversial discussion. Let’s start with describing the nature of this disorder. So, the intestinal epithelial lining, together with factors secreted from it, forms a barrier. But in pathologic conditions, the permeability of the epithelial lining may be compromised allowing the passage of toxins, antigens, and bacteria in the lumen to enter the blood stream creating a “leaky gut.” In individuals with a genetic predisposition, a leaky gut can allow environmental factors to enter the body and trigger an autoimmune disease. In most cases, poor nutrition is the cause of this condition. Stress or long-term use of non-steroidal anti-inflammatory drugs (such as aspirin or ibuprofen) may be another cause. In addition, gut microbiota plays a huge role in maintaining the epithelial barrier. Research has shown that the intestinal microbiome plays an important role in modulating risk of several chronic diseases, including inflammatory bowel disease, obesity, type 2 diabetes, cardiovascular disease, and cancer. When leaky gut syndrome is suspected, you can do Zonulin faecal test. Zonulin is an effective tool for monitoring the levels of zonulin as elevated levels of this protein to be the potential doorway to leaky gut syndrome, chron’s and other inflammation, autoimmunity and gastro-intestinal diseases. RELATED ARTICLES How to normalize your gut microbiota Changing microbial composition through diet can have significant therapeutic value. First, proper nutrition leads to a decrease in inflammation. It allows the mucous membrane to heal. When it comes to nutrition, we need to mention  low glycemic and high fiber foods again. Secondly, some foods and drugs, such as alcohol, caffeine, and NSAIDs can irritate the small intestine. Therefore, it is advised to avoid them. Now, a few words about fermented foods containing lactic acid bacteria: fermented milk products and yoghurt are a source of edible microorganisms. As such, they can beneficially regulate gut health and even treat or prevent inflammatory bowel disease. Lactobacillus and prebiotics Lactobacilli and prebiotics can also be of use to you. Studies show that taking probiotics can effectively replace pathogenic bacteria in the gut with beneficial cultures. It has also been proven that nutrients, prebiotics, and even plant extracts (e.g., indigo naturalis) improve barrier function, which we wrote about above. In addition, intake of probiotics, as well as yoghurt containing probiotics, caused a reduction in triglycerides, total cholesterol, LDL-cholesterol, VLDL-cholesterol, and high-sensitivity C-reactive protein (hsCRP). In a number of other studies, taking lactobacillus (Lactobacillus bulgaricus) together with the prebiotic fructo-oligosaccharides (FOS) resulted in significant improvements in inflammatory, metabolic and enzymatic performance. And since we mentioned fructooligosaccharide, let’s say a few words about it. First, this naturally occurring prebiotic, which contains fiber, provides additional nutrition for beneficial gut bacteria. As a rule, it is recommended to take it 2-5 g per day. Second, it is also among the top 8 prebiotic fiber with ample evidence for digestive health, along with lactulose. So fructo-oligosaccharide (FOS) is a very well-established prebiotic! Enzymes to facilitate digestion Among other things, supplementation with enzymes helps break down food to facilitate digestion. For example, digestive enzymes are able to break down proteins, carbohydrates and lipids, and adding them to a diet may play a role in the treatment of digestive disorders, from lactose intolerance to cystic fibrosis.Besides, supplements containing garlic, bioflavonoids, and aloe vera may help the situation as well. Among other things, the Doctor may also recommend a food allergy test. It’s value is in identifying foods that irritate your digestive system. These might include wheat, dairy products, or citrus fruits. Irritable bowel syndrome One of the most common digestive disorders of the lower gastrointestinal tract is irritable bowel syndrome (IBS). It is a chronic and debilitating functional gastrointestinal disorder that affects 9–23% of the world’s population (World Gastroenterology Organization, 2009). There are no tests to diagnose it. As a rule, it is identified through the process of elimination, when research does not confirm other disorders. The exact cause of IBS is still unclear. The symptoms of this disease can vary from patient to patient and change over time. Patients report that the most disturbing symptoms are abdominal pain, colic, pain, bloating, diarrhea, constipation, and a feeling of incomplete bowel movement. Upper GI abnormalities such as heartburn, nausea, and excessive belching often accompany these symptoms. Treatment Let’s take a look at what can help people with these disorders. First, research shows a clear relationship between this disease and fat intake. So, with an increase in fat intake, both the amount of stool and diarrhea increase. In addition, long-term consumption of unhealthy fats, refined sugars, and starch can cause irritation and inflammation. Such products contribute to the development of inflammatory processes. And, of course, there is a connection between IBS and stress. So practice relaxation, meditation,

digestive disorders

DIGESTIVE DISORDERS CAUSES: PART 1

DIGESTIVE DISORDERS CAUSES: PART 1 Read More »

The food you choose has a major impact on your health and life expectancy. However, it is not only the quality of products which is important, it is also important how well they are absorbed. So let’s take a look at the most common causes of digestive disorders. Unfortunately, the article is longer than we planned. First, because it contains most common disorders. Secondly, in addition to describing the problems, we also explain how to improve digestion. This article was last reviewed by Svetlana Baloban, Healsens, on January 24, 2020. This article was last modified on 15 October 2020. If you think that digestive disorders are an inevitable part of our life, then you should know that this is far from the case. Like many chronic diseases, they can result from inappropriate habits. For example, think about proper nutrition and related digestive disorders. This is important, since gastrointestinal disorders are far from uncommon! More than 40% of people worldwide suffer from them. The magnitude of the problem is also reflected in the ever-increasing consumption of over-the-counter gastrointestinal drugs to relieve the symptoms of digestive disorders. So, some digestive disorders can be inherited, others acquired. So, genetic defects include lactose intolerance, which means inability to digest milk sugar. The celiac disease also needs be mentioned, although the disease is not inherited. However, susceptibility to its development can also be inherited. Note that celiac disease is a multifactorial disease. This means that several genes at once interact with environmental factors to cause it. IN THIS ARTICLE 1 Digestive disorder causes 2 Improper food chewing 3 Vitamin B12 deficiency 4 Helicobacter Pylori 5 Lactose intolerance RELATED ARTICLES Most ailments occur due to the additional stress that our digestive system experiences as a result of poor nutrition. On the one hand, certain supplements or medications help to cope with the problem. On the other hand, healthy eating is still the most important thing for restoring and maintaining healthy digestion. Digestive disorder causes There’s nothing new in the fact that one’s diet provides nutrition needed for energy, growth, and recovery. But apart from that, it also affects and regulates several important functions of the body. For example, proportions of proteins, carbohydrates and fats control the type and amount of gastrointestinal hormones released into the bloodstream. These hormones regulate gastrointestinal motility, secretion and absorption, cell proliferation, appetite, and local immune defenses. Furthermore, the gastrointestinal hormonal peptides/amines interact and integrate with the enteric, autonomic, and central nervous systems (gut-brain axis). Food intake also affects the gut microbiota. Microbiota, in turn, plays an important role in health and disease. In general, food makes many stops during the digestion process, which can potentially be disrupted. Improper food chewing Children often are told to take their time and chew food well. And this makes sense! Improper chewing of food puts additional stress on the gastrointestinal tract. This is due to the need for an increased amount of digestive juices, which will be required to break down large pieces of food. This can cause gas and bloating. And in the future, it can lead to more serious problems in the digestive system. Therefore, you should chew slowly, enjoy the taste, and chew each bite thoroughly. In addition, the number of teeth also affects the chewing quality. So, for example, a number of studies have confirmed that the more teeth, the better a person can chew and the more he does not consume foods rich in fiber, vitamins, folic acid, calcium and protein. Difficulty in chewing fiber rich foods can be associated with increased risk of systemic illness, such as cardiovascular disease, and with oral diseases, such as oropharyngeal cancer. Therefore, we should take care of our teeth and enjoy our food, chewing it thoroughly. So, you will have more pleasure and the gastrointestinal tract will be grateful to you. Vitamin B12 deficiency When food enters the stomach, an intrinsic factor (IF) is released. The intrinsic factor (IF) is a glycoprotein that plays a crucial role in the transportation and absorption of vitamin B12. Insufficient release of intrinsic factor (IF), can result in deficiency of this vitamin. If such a disbalance is not eliminated, it can lead to adverse events. These include such disorders as anemia, overwork, tingling or numbness of fingers and toes, imbalance, depression, and even dementia. Inadequate excretion of this element may be corrected with supplements containing IF and vitamin B12. Remember that vitamin B12 coming in from outside loses its properties in the gastrointestinal tract. Therefore, it is recommended to be taken in the form of injections or sublingual tablets. Helicobacter Pylori Another problem that can appear during digestion is the bacteria Helicobacter pylori. Helicobacter pylori (H. pylori) is a bacterium that infects up to 50% of the world’s population. H. pylori can disrupt the delicate balance between highly acidic gastric juice and mucus. Therefore, they are the most important cause of chronic or atrophic gastritis, peptic ulcer disease, lymphoma, and gastric carcinoma. Typically, this H. pylori infection is acquired in early childhood and persists without treatment. It should be added that the majority of children with H. pylori infection are asymptomatic. And if any symptoms are present, they are usually associated with gastritis or ulcer disease. Furthermore, the presence of Helicobacter may be associated with anemia. Thus, it has been documented that those infected with H. pylori have lower iron stores. So, if there are any concerns, the doctor may suggest a Helicobacter pylori antibody blood test. Lactose intolerance We have already mentioned above about lactose intolerance. Now we will dwell on its specifics in more detail. So, lactose intolerance is a clinical syndrome that manifests itself with characteristic signs and symptoms when using lactose, a disaccharide. Usually, when lactose is consumed, it is hydrolyzed to glucose and galactose by the enzyme lactase. Lactase deficiency leads to clinical symptoms such as nausea, colic, gas and diarrhea. The severity of the disease varies from person to person. In many people, the amount of lactase produced decreases with age. In addition to the age

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