Healsens - Discover your health risks, get insights for longevity | Product Hunt

Cancer Prevention

Cancer prevention includes actions to lower the risk of getting cancer. This can include maintaining a healthy lifestyle, avoiding exposure to known cancer-causing substances, and taking medicines or vaccines that can prevent cancer from developing.

treatment for vitamin d deficiency

TREATMENT FOR VITAMIN D DEFICIENCY

Vitamin D deficiency affects people of all ages. Last time we analyzed in detail how a deficiency of this vitamin affects our health. This time we will talk about natural and medical treatment for vitamin D deficiency.

This article was last reviewed by Svetlana Baloban, Healsens, on October 24, 2020. This article was last modified on 29 October 2020.

Let us start with how we define vitamin D deficiency.

In summary, a deficiency occurs when the serum 25-hydroxyvitamin D level is less than 20 ng/ml (50 nmol/L)12.

If your serum 25-hydroxyvitamin D level is between 20 and 30 ng/ml (50 to 75 nmol/liter), then we are talking about vitamin D insufficiency.

Values of less than 10 ng/ml refer to severe vitamin D deficiency. We will analyze the approach to treat this deficiency separately.

Treatment for vitamin D deficiency

Sunbathing, which we wrote about last time, is a great way of treating vitamin D deficiency. Another way to increase vitamin D levels in the body is food. In spite of the fact that food will not give you as much vitamin D as the sunlight, when combined with sun exposure it will work quite well. So make sure that your winter and summer diet includes oily fish (salmon, mackerel, tuna), egg yolks, cheese, liver, as well as enriched dairy and cereal-grain products.

RELATED ARTICLES

In addition to sunbathing, those who have a lack of vitamin D (especially with critical numbers, when 25 (OH) D is less than 20 ng/ml) are advised to take vitamin D as a supplement. It should be said that an increase of 25(OH)D levels through dietary intake is quite individual.

How much vitamin D should I take if I’m deficient?

So, the amount of vitamin D needed to treat a deficiency depends largely on the degree of the deficiency and the underlying risk factors.

Initial supplementation with Vitamin D3 for 8 weeks, either 6,000 IU daily or 50,000 IU weekly, can be considered34. When the vitamin level exceeds 30 ng/ml, the daily maintenance dose will be 1000 to 2000 IU.

Higher-risk adults may require higher starting doses of vitamin D3. These people include African Americans, Hispanics, people with obesity, chronic illness, and taking certain medications. Typically, your doctor may prescribe 10,000 IU of vitamin per day. For such people, maintenance doses can range from 3000 to 6000 IU / day. So if you are at risk, it is better to discuss the treatment with your doctor. This is due to the fact that for some diseases, an individual approach to the dosage of vitamin D is required.

It is recommended that both D2 and D3 be taken with a diet containing fat to ensure maximum absorption.

Don’t be surprised if it will take you half a year or more to achieve the optimum levels of this vitamin. Furthermore, when the desired level of vitamin D is achieved, to sustain it you will need to take 1000-2000 ME a day and regularly control its level to prevent its overaccumulation in your body. Vitamin D3 (cholecalciferol) is considered to be more effective than vitamin D2 (ergocalciferol), although some recent studies have proven them equally effective.  

The dosage of vitamin D to correct severe vitamin D deficiency (<10 ng/mL)

Although not validated by clinical trials, a commonly applied strategy is to prescribe a “loading dose”. For example, 50,000 IU of vitamin D orally once weekly for 2-3 months, or 3 times weekly for 1 month5.

On the other hand, treatment regimen studies have shown that a minimum total dose of 600,000 IU was most effective in achieving vitamin D sufficiency6.

The study examined the following common treatment regimens, namely:

  • 50,000 IU of D2 once weekly for 4 weeks followed by 50,000 IU once monthly for 5 months;
  • D2 50,000 IU once monthly for 6 months;
  • D2 50,000 IU 3 times weekly for 6 weeks.

Regimens where vitamin D2 intake> 600,000 IU administered over an average of 60 +/- 40 days provided the best option without vitamin D toxicity.

Follow us on Facebook|| Instagram || Telegram || Youtube

Maintenance Dose of Vitamin D

The recommended concentrations of 25(OH)D vary from 30 to 60 ng/mL. There is currently no evidence that values of 61-100 ng/mL provide health benefits. Along with taking preventing and maintaining doses, it is advisable to test your 25(OH)D in blood every 6-12 months. First of all, this recommendation is associated with a risk of falling below the levels of vitamin D. For example, some studies suggest that a maintenance dose of 2,000 IU of vitamin D may not be sufficient7.

It’s worth noting that in order to prevent vitamin D deficiency people aged 18-50 should receive 600-800 ME a day, those older than 50 – as much as 800-1000 ME a day. It is not recommended to prescribe more than 10,000 ME a day for a long period (more than 6 months) without medical supervision and control. Due to its lipophilicity, its accumulation in fat tissue may result in vitamin D becoming toxic.

Unlock your health insights with our smart data analysis – the Free Health Tracker app, your reliable medical record!

Drastically reduce the time to detect chronic diseases & inspire healthy habits



FURTHER READING

Follow us on Facebook|| Instagram || Telegram || Twitter || Youtube

Source: ©️2019 Healsens B.V. All right reserve

TREATMENT FOR VITAMIN D DEFICIENCY Read More »

breast cancer risk factors

THE MAIN RISK FACTORS OF BREAST CANCER

1 in 8 women will develop breast cancer (BC) in their lifetime1. More than 2 million new cases of this disease are diagnosed worldwide every year2. There are of course breast cancer risk factors.

What do you need to know to prevent illness? Is it possible to reduce your own risk of developing breast cancer? Let’s find out.

Written by Y. Timovskaya, Ph.D., doctor oncologist of the highest category, Member of ESMO. Together with @ Galishina Anna – Head of the Diagnostic Department of the Specialized Breast Center, doctor of radiation diagnostics of the highest category, member of ESR, EUSOBI.

8 major risk factors

It’s possible to conditionally identify the main factors in the development of breast cancer. There are only 8 of them! Of course, in general, there are many more risks and we have already written about some little-known ones. But the most significant are the following:

  1. Female gender. More than 80% of all breast cancer cases in the world are women.
  2. Age – the risk of developing breast cancer significantly increases with age. So, the peak incidence is observed at the age of 55-65.
  3. Complicated family history of breast cancer, ovarian and intestinal cancer.
  4. The presence of mutations in the brca genes.
  5. Metabolic disorders (obesity, diabetes mellitus, and insulin resistance).

RELATED ARTICLES

6. Hyperestrogenemia (increased concentration of estrogens in the blood), especially associated with the intake of hormonal drugs. And these are combined oral contraceptives (COCs), and hormone replacement therapy (HRT), and IVF.

7. Failure to comply with the healthy lifestyle rules, which leads to metabolic disorders.

8. Not having children or lactation or late childbirth.

New risks

In addition to the main risks, there are few that we are able to influence. They include:

👉 Low level of vitamin D3.

Research suggests that women with low levels of vitamin D have a higher risk of breast cancer. This happens because vitamin D may play a role in controlling normal breast cell growth and may be able to stop breast cancer cells from growing.

👉Exposure to Chemicals in Cosmetics4

So, research strongly suggests that at certain exposure levels, some of the chemicals in cosmetics may contribute to the development of cancer in people. Such substances include parabens (the most common are methylparaben, propylparaben, ethylparaben and butylparaben) and phthalates.

👉Exposure to Chemicals in Food5

There’s a real concern that pesticides, antibiotics, and hormones used on crops and livestock may cause health problems in people, including an increase in breast cancer risk.

Now let’s talk about why we need all this information and what is the practical use of it?

Why understand your risk factors?

Do all factors in the breast cancer development lead to the development of breast cancer? No.

Did all breast cancer patients have all these risk factors? No either.

At the same time, a combination of risk factors increases the risk of developing breast cancer. However, it is not yet possible to determine exactly which of 8 women will develop the disease. Yet doctors talk about the importance of understanding risk factors. But why?

There are situations when a woman has all the risk factors, and at the same time, she will never get sick with this disease. On the other hand, there are diametrically opposite situations when a woman does not have any risk factors except the first one, and she still gets breast cancer. However, such situations are marginal. They are located at the edges of the variation row for breast cancer patients.

In most cases, that is in 80% of patients with breast cancer, known risk factors played a role in the disease development. Thus, women very often unconsciously provoked progressing tumor processes through their actions. And a major part of the cause of this problem was ignorance. In other words, many people have never heard of risk factors that subsequently cost them their health. Therefore, all over the world, the information war against breast cancer is recognized as one of the most effective mechanisms to reduce mortality from this disease.

Follow us on Facebook|| Instagram || Telegram || Youtube

Variable and permanent breast cancer risk factors

It should be noted that risk factors can be divided into two groups. The first one includes those that we cannot affect, such as gender, age, family history, and the presence of gene mutations. In this case, if you are aware of them, your doctor should adopt an individual preventive care program and screening diagnostics. In all the other cases, it’s up to us to influence the risk factors. Thereby we can reduce our own risk of developing breast cancer.

It is important not only to know about breast cancer risk factors but also to realize that our health may depend on us. Of course, it is not possible to prevent breast cancer with 100% certainty. At the same time, we can reduce the risk of death through early diagnosis. Therefore, it is necessary to take into account the presence of risk factors and behave accordingly, considering your risk group.

Patients’ stories

So now, let’s get from theory to practice. We’ll go over two cases to illustrate how important it is to understand your risks. Subsequently, we will definitely devote a few future articles to this topic.

👉 Case 1. A 38-year-old woman with a family history of breast cancer. She didn’t have childbirth and lactation, but there is a record of pregnancy termination in her history at the age of 27. Since then, she has been constantly taking combined oral contraceptives (COCs) for contraception.

👉 Case 2. A 52-year-old woman with climacteric syndrome, type 2 diabetes, a history of 1 childbirth at 22, no lactation, 4 abortions, the last one at the age of 42. She has been taking hormone replacement therapy (HRT).

So, patients already have risk factors for developing breast cancer, which they cannot change. But these women increased the risk of the disease by taking additional hormonal estrogen-containing drugs. Of course, in spite of the above cases, not everyone using HRT will develop breast cancer. However, when the disease is already there, oncologists always hear regrets about the lack of awareness. If they had known that they had been increasing the risk, they would have acted differently. Only 1 in 8 factors is enough to play a key role in cancer development. Don’t add risks yourself. Take care of yourself.

First of all, forewarned is forearmed☝️. Awareness reduces breast cancer mortality.

Unlock your health insights with our smart data analysis – the Free Health Tracker app, your reliable medical record!

Drastically reduce the time to detect chronic diseases & inspire healthy habits



FURTHER READING

Follow us on Facebook|| Instagram || Telegram || Twitter || Youtube

Source: ©️2019 Healsens B.V. All right reserve

THE MAIN RISK FACTORS OF BREAST CANCER Read More »

vitamin D

VITAMIN D FUNCTION AS THE OVERALL HEALTH HORMONE

Modern books on wellness management often mention Vitamin D. It is commonly called overall health hormone1. And it makes sense! Vitamin d function is to help prevent chronic diseases and affect people’s longevity in general. Meanwhile, vitamin D insufficiency affects almost 50% of the population worldwide. An estimated 1 billion people worldwide, across all ethnicities and age groups, have its deficiency. That is and why sustaining its optimum level is critically important for your health.  

What is unique about vitamin D is that we don’t only get with food but can also produce it in our body by being exposed to sunlight. It plays a major role in keeping bones healthy, therefore it insufficiency can lead to child rickets, and adult malacosteon (bone softening) and osteoporosis (bone loss). But this vitamin’s role is not limited to this function.

Role of Vitamin D

Some recent studies have shown that it sufficiency is also associated with lower risks of getting diabetes milletus, multilocular sclerosis, cardiovascular diseases2, and tuberculosis3.

RELATED ARTICLES

Besides, it is vital for a healthy immune system4. Without sufficient its amount our immune cells cannot properly react to threats, making our body more vulnerable to infections. In addition, vitamin D affects both inborn and acquired immunity.

It’s worth mentioning that vitamin D has anti-cancer effect for various types of cancer5. Emerging research supports the possible role of it against cancer, fractures and falls, autoimmune diseases6, influenza, type-2 diabetes, and depression. That’s why many health care providers have increased their recommendations for vitamin D supplementation to at least 1000 IU7. So, a meta-analysis published in 2007 showed that this supplementation was associated with significantly reduced mortality.

By now we have received the evidence of an increased risk of prostate and endometrium cancer, esophageal, stomach and pancreatic cancer, bladder and renal cancer, Hodgkin’s disease and non-Hodgkins lymphoma caused by vitamin D deficit.

It is remarkable that randomized double-blind examination shows significant 60% decrease in general oncological risk among postmenopausal women who were treated with vitamin D and calcium, as opposed to those who received placebo treatment during 4 years of observation8. The studies show the optimum 25 (OH)D in blood serum for cancer prevention to be 40-60 ng/mL (100-150 nmoles/L).

In addition, lower levels of vitamin D adjusted for BMI are also associated with an increased risk of hypertension9. Therefore, given the relatively safe and inexpensive route of vitamin D supplementation, some studies recommend prescribing vitamin D to hypertensive patients who fall below the target.

Chronic fatigue, low spirits may also be caused by vitamin D insufficiency. Besides, muscle weakness is considered a clear indicator of its clinical deficiency. Clinical symptoms of myopathy deficiency include proximal muscle weakness, diffusive muscle pains, and balance disorder. It also reduces age-related and general inflammations, which is critically important for cognitive function retention.

Follow us on Facebook|| Instagram || Telegram || Youtube

How to Measure Vitamin D Levels

Your vitamin D can be tested in a blood test which measures its content (25-OH vitamin D). 25(OH)D is the main metabolite of it in the blood. Two main forms of 25(OH)D are cholecalciferol (D3) and ergocalciferol (D2). D3 is mainly formed in our skin under ultra-violet rays, while the source of D2 is food. Significantly, 25(OH)D concentration is made up of these two components, both forms are measured equimolarly. 25(OH)D is considered the best indicator of vitamin D in the body.  

Sun Exposure and Vitamin D

As mentioned above, you can get enough vitamin D in daily sun exposure. It happens because sunlight enables our body to synthesize it from cholesterol. To achieve this effect, some scientists recommend exposing about a third of your skin to the sun. This means that for most fair-skinned people, wearing a T-shirt and shorts for 10-30 minutes three times a week during the summer will be sufficient10. People with darker skin may need a bit longer than this.

However, a Korean study did not confirm the effectiveness of this recommendation. The experiment was Korean adults aged 20–49 years with serum 25-hydroxyvitamin D (25[OH]D) levels of < 20 ng/mL11.

The results showed that the sunlight exposure group showed a slight increase in serum 25(OH)D level. The sunlight exposure group had sunlight exposure on 20% to 30% of their body surface areas for 30–60 minutes per day, 3 times a week during the summer season.

Let’s see how much of vitamin D can be obtained through sunbathing? A Norway study found that 30 minutes of midday summer sun exposure of the whole skin is equivalent to taking 10,000-20,000 IU vitamin D orally12. At the same time, the winter levels of vitamin D are 10 to 100% lower than the summer levels. That means people in Norway cannot get vitamin D from sunlight between October and March.

There are a lot of factors that can affect your ability to make vitamin D from sunlight. Firstly, it depends on how sensitive your skin is to sunlight. Other factors include the time of day, your skin color, and how far you live from the equator. Secondly, it should be taken into account how much skin you expose to sunlight and whether you’re wearing sunscreen.

Does sunscreen reduce vitamin D production?

Since we mentioned sunscreen, let’s see how it affects vitamin D. Some studies estimate that sunscreen of SPF 30 or more reduces vitamin D production in the body by about 95–98%13. However, several studies have shown that wearing sunscreen has a small impact on your blood levels during the summer141516. Perhaps the differing results are related to different factors and the duration of the experiments. Another possible explanation is that even though you are wearing sunscreen, staying in the sun for a longer period may cause enough vitamin D to be made. Anyway, the effect of sunscreens on circulating vitamin D levels remains debated.

In conclusion, in order to resolve the dilemma of sunscreens, you may try going without sunscreen for just the first 10–30 minutes. This period should depend on how sensitive your skin is to sunlight. And then you need to apply sunscreen before you start burning.

This article was last reviewed on 12 March 2020. This article was last modified on 10 February 2020.

Unlock your health insights with our smart data analysis – the Free Health Tracker app, your reliable medical record!

Drastically reduce the time to detect chronic diseases & inspire healthy habits



FURTHER READING

Follow us on Facebook|| Instagram || Telegram || Twitter || Youtube

Source: ©️2019 Healsens B.V. All right reserve

VITAMIN D FUNCTION AS THE OVERALL HEALTH HORMONE Read More »

Get the Healsens app

Choose either App Store or the Google Play, then scan the displayed QR code with your phone.

You have successfully subscribed to the newsletter

There was an error while trying to send your request. Please try again.

Healsens Digital Preventive Healthcare will use the information you provide on this form to be in touch with you and to provide updates and marketing.

Мы пока работаем над сравнением цен на анализы различных лабораторий. Спасибо за интерес и оставайтесь с нами на связи!

Поздравляем! Вы успешно подписались!

Произошла ошибка. Попробуйте еще раз

Healsens Digital Preventive Healthcare will use the information you provide on this form to be in touch with you and to provide updates and marketing.

We're working to make this feature workable. Thanks for your interest! Subscribe to be the first user and get a 10% discount

You have successfully subscribed to the newsletter

There was an error while trying to send your request. Please try again.

Healsens Digital Preventive Healthcare will use the information you provide on this form to be in touch with you and to provide updates and marketing.