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Biological age blood test·
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health risk assessment

Biologische leeftijd berekenen

Biological Age Blood Test

Biological Age Blood Test Read More »

Did you know that you can determine your biological age through a simple blood test? While your chronological age is based on your date of birth, a biological age blood test measures various biomarkers to determine how well your body is aging. By taking this test, you can gain valuable insights into your overall health and identify areas where you may need to make lifestyle changes to improve your biological age. So, why should you care about your biological age? Well, research has shown that people with a higher biological age than their chronological age are at a greater risk for age-related diseases like heart disease, Alzheimer’s, and cancer. However, the good news is that you can take steps to reduce your biological age and lower your risk of these diseases. Package of lab tests to calculate biological age: IN THIS ARTICLE 1 For whom is this product intended? 2 Discover Your True Biological Age with a Blood Test: Why Should You Get Tested? 3 Why should you trust Healsens to calculate your biological age? RELATED ARTICLES For whom is this product intended? Biological age is a measure of an individual’s health and physical condition that goes beyond their chronological age. While we all age, the rate and manner of aging can differ significantly between individuals, based on lifestyle habits, genetics, and other factors. Measuring biological age can help individuals understand how their bodies are aging and identify areas for improvement in their health habits. One tool for measuring biological age is Levine’s Phenotypic Age calculator, which uses a combination of biological markers to estimate an individual’s age at the cellular level. So, for whom is this product? In short, anyone who is interested in their health and wants to take a proactive approach to aging. Individuals who want to optimize their health and longevity may benefit from using Levine’s Phenotypic Age calculator. This tool can be particularly useful for individuals who are at higher risk for age-related diseases, such as heart disease or cancer, or who have a family history of such conditions. Furthermore, individuals who have experienced significant changes in their lifestyle or health status may also benefit from measuring their biological age. For example, if someone has recently quit smoking, started exercising regularly, or made significant changes to their diet, measuring their biological age can provide an objective measure of the impact of these changes on their health. Discover Your True Biological Age with a Blood Test: Why Should You Get Tested? But why should you purchase lab tests to calculate your biological age? The main reason is that it provides valuable information about your overall health status and can help identify areas for improvement. By knowing your biological age, you can make informed decisions about your health and lifestyle, such as increasing physical activity, improving diet, or reducing stress levels. Moreover, measuring biological age can help you detect potential health issues early on when they are more manageable. For example, if someone’s biological age is significantly higher than their chronological age, it may indicate that they are at higher risk for age-related diseases, such as heart disease or cognitive decline. Armed with this knowledge, you can take proactive steps to reduce the risk and improve your overall health and well-being. In conclusion, measuring biological age using Levine’s Phenotypic Age calculator can provide individuals with valuable insights into their health and aging process. By understanding your biological age, you can take a proactive approach to your health and make informed decisions about your lifestyle habits. With this information, you can optimize their health and well-being and potentially increase their lifespan. » Explore everything about the significance of High Platelet Count results mean. How to Order Biological Age Blood Test? If you are interested in checking your biological age, you can easily purchase a blood test kit from Healsens. 1 Download the Healsens App from Google Play or the App Store, depending on your device. 2 Complete the registration process in the app. 3 Go to the “Risks” page via the bottom menu of the application. 4 Tap on the test you need — ”Levine’s Phenotypic Biological Age” 5 Tap on the “Add to Cart” button inside the test page and proceed with the ordering process. Process of taking blood tests in: Labplusarts ↗ Bloedwaardentest ↗ » Unlock Optimal Health: Discover How a Personalized Healsens General Check-up Plan Can Transform Your Well-being. Note If you want to assess your biological age but are not residing in the Netherlands or have opted for a different laboratory, Healsens cannot upload your blood test results for you. Nevertheless, you have the option to undergo the required tests at any laboratory in your country and manually input the obtained results into the application. Healsens will open more opportunities for you to naturally normalize your blood test results. Furthermore, you gain full access to investigate your health risk assessment based on the provided data. Why should you trust Healsens to calculate your biological age? Healsens is committed to providing you with accurate and reliable results that you can trust. We partner with Medical Laboratories Dr. Stein & Collegae, a highly respected and accredited laboratory in the Netherlands, to ensure that your blood samples are processed with the utmost care and accuracy. Lab Stein has an excellent reputation within the Dutch healthcare sector. With more than 20 medical specialists (laboratory doctors), chemists, biologists, doctors-microbiology etc. and 600 employees, the laboratory is one of the three largest medical laboratories in Europe. They carry out more than 5 million tests per year. Furthermore, we use Levine’s Phenotypic Age calculator to estimate your biological age. This algorithm has been proven with high accuracy in multiple studies and is widely accepted as a reliable method for calculating biological age. At Healsens, we understand that not everyone is comfortable with preventive medical examinations without a referral from their general practitioner. That’s why we work with our partners to ensure that our tests are conducted with the highest standards

Соотношение кортизол/ДГЭА-С

Cortisol/Dhea-S Ratio Of Longevity

Cortisol/Dhea-S Ratio Of Longevity Read More »

A complex interaction between cortisol and dehydroepiandrosterone-sulphate (DHEA-S) is crucial in the stress system balance. In particular, significantly higher or lower cortisol/DHEA(S) ratios have been associated with depression and aggression. In general, DHEA-S levels affect various body systems, as well as prevent aging (Chahal and Drake 2007). That is why the Cortisol DHEA ratio is a very informational indicator, which, along with other indicators calculated in Healsens, provides important information about human health. Thus, using the ratio of cortisol / DHEA-S, you can assess body responses to exercise or evaluate mental health. Another benefit is that you can check your cortisol and DHEA-S levels at home. This article was last reviewed by Svetlana Baloban, Healsens, on January 24, 2020. This article was last modified on 4 March 2021. How Cortisol and DHEA Sulfate Affect the Body Let’s start by looking at how cortisol and DHEA-S affect overall health. Dehydroepiandrosterone (DHEA) and cortisol are produced in the adrenal glands and are both derived from pregnenolone. So, DHEA and DHEA-S production reaches its peak at the age of 20–30 and then declines progressively with age. When it comes to cortisol levels, while some studies show that cortisol increases with age, others do not support this observation. However, everyone agrees that the reduction in DHEA-S entails disruption of various physiological systems. Stress Level As mentioned above, DHEA and DHEA-S play a protective role during acute stress as an antagonist to the action of the stress hormone cortisol. In turn, cortisol also helps to effectively manage stress. Let’s see how this happens. About 15 minutes after a stressful situation, cortisol levels rise and remain elevated for several hours. This marks the onset of stage 1. During this stage, there are elevations in cortisol with no corresponding changes in DHEA. Subsequently, glucose is mobilized, non-essential organ systems are suppressed, and inflammation is reduced. All of these physiological responses collectively enable the body to effectively cope with stress. However, in cases of chronic stress, this adaptive reaction can take a catastrophic turn: cortisol loses its ability to function normally. This transition ushers in stage 2. In this latter stage, the persistence of stress leads to a sustained peak in cortisol levels, matched by a corresponding elevation of DHEA. IN THIS ARTICLE 1 How Cortisol and DHEA Sulfate Affect the Body 2 Assessing Exercises 3 Adrenal/DHEA Restoration RELATED ARTICLES It becomes increasingly challenging to maintain appropriate blood sugar levels, to allow for adequate rest, to achieve high-quality sleep, and to achieve a harmonious balance among other hormones. This signals the arrival of stage 3, wherein stress persists and becomes chronic. During this stage, cortisol levels decrease, while DHEA remains elevated. In the absence of timely intervention, prolonged adrenal hyperstimulation can result in adrenal exhaustion. This condition is eventually manifested by a decline in both cortisol and DHEA, a phase often denoted as adrenal exhaustion or stage 4. Ultimately, this process may culminate in adrenal failure. Thus, the optimal ratio between salivary cortisol and DHEA is approximately 5:1 to 6:1, serving as an indicator of a normal state of adaptation to stress. When the body’s ability to maintain its normal stress adaptation is compromised, a process known as stress maladjustment can ensue. This phenomenon is now recognized as a chronic stress response, often identified by terms like pregnenolone steal, cortisol escape, or an elevated cortisol to DHEA ratio. The longer one remains in a state of chronic stress, the more pervasive its negative impact becomes on various aspects of physical well-being. As a result, individuals grappling with depression or heightened anxiety levels (measured at 0.24 ± 0.03 in the healthy group compared to 0.41 ± 0.12 in the group of individuals with severe anxiety), along with those dealing with post-traumatic stress disorder, exhibit disruptions in the cortisol to DHEA ratio. Nevertheless, it’s worth noting that certain studies have demonstrated the potential of DHEA treatment to mitigate the adverse health effects associated with stress. Musculoskeletal disorders We have already mentioned that cortisol dysfunction entails disorders of the musculoskeletal system. Thus, the higher the cortisol / DHEA-S ratio, the more serious the risk of this problem. Moreover, multiple regression analysis showed that the independent risk factor for sarcopenia was a serum cortisol/DHEA-S ratio ≥ 0.2. Sarcopenia is a type of muscle loss that occurs with aging and/or immobility. Immunity and Cortisol DHEA Ratio In addition, an increase in the cortisol / DHEA-S ratio with age (Phillips et al. 2007) is associated with immune dysfunction and the risk of infection in the elderly due to the fact that DHEA-S enhances immunity. However, cortisol has an inverse immunosuppressive effect (Buford and Willoughby 2005). It is also worth adding that DHEA-S is known for its antioxidant properties. Metabolic Syndrome Various studies have shown that both cortisol and DHEAS are related to metabolic syndrome, and type 2 diabetes. While high cortisol concentrations are associated with an increased risk of metabolic syndrome, high DHEA-S levels appear to be protective. By far, the strongest associations were observed for the cortisol / DHEA-S ratio. According to observations, the higher the coefficient, the greater the risk of metabolic syndrome. This ratio is also strongly associated with four of the five components of metabolic syndrome. Alzheimer’s Disease The cortisol / DHEA-S ratio may also be crucial in Alzheimer’s disease. For example, some studies have found a link between the cortisol / DHEA-C ratio and a decrease in hippocampal volume. It is worth saying that a decrease in the volume of the hippocampus is one of the early diagnostic signs of Alzheimer’s disease. This finding has been confirmed by other studies, observing the relationship between cortisol / DHEA-S and hippocampal atrophy (HA). For example, such a direct relationship was observed in patients with Cushing’s syndrome. Moreover, HC volume partially recovered following treatment-induced cortisol decrease. However, not all studies support this association within normal cortisol levels in healthy people. To sum up, the ratio of cortisol / DHEA sulfate can reflect: Assessing Exercises DHEA (Aldred et al. 2009; Cumming et al. 1986) and DHEA-S (Tremblay et al.

cardiovascular risk assessment

CARDIOVASCULAR RISK ASSESSMENT

CARDIOVASCULAR RISK ASSESSMENT Read More »

Cardiovascular diseases such as ischemic heart disease, thrombosis, arterial hypertension with its complications – myocardial infarction and stroke – constitute a dynamic multistep process that is closely related to inflammation. It is well-known that CVD diseases rank first among all other diseases of mankind. Traditionally for making an accurate diagnosis, the patient must undergo a series of procedures, undergo lab tests so that the doctor can prescribe the necessary treatment. However, there is another way. Doctors can use cardiovascular risk assessment tools aimed at detecting the disease at an early stage. This time, not only will we consider different methods / risk calculators that are now used in clinical practice, but we will also make the corresponding calculations using a real example of a patient’s history. And, of course, let’s talk about why, given the presence of such intelligent systems, the CVD problem is still relevant. This article was last reviewed by Svetlana Baloban, Healsens, on January 24, 2020. This article was last modified on December 15, 2020. Why do you need cardiovascular risk assessments? Before proceeding to describe various calculation methods, let’s find out why they are needed at all. To begin with, we shall that most heart diseases develop completely asymptomatically over many years. In practice, it means that if one doesn’t feel any health problems, he or she simply does not go to the doctor unless a critical condition occurs. So, according to some estimates, 3.7 million Americans remain with undiagnosed heart disease. At the same time, the highest proportion of undiagnosed CVDs, which led to death from cardiovascular diseases, is among people aged 18–59 years. This is especially true when you consider that obesity, type 2 diabetes, and other risk factors are becoming more common at a young age. Second, understanding the risks allows for early diagnosis of CVD and, accordingly, preventive lifestyle interventions or treatment as needed. And thirdly, the assessment of risk factors can clearly demonstrate how the total risk changes if you switch to a healthier lifestyle. That is why, as early as in 1948, the Framingham Heart Study was initiated under the direction of the US National Heart, Lung, and Blood Institute. It was an ambitious medical research project that changed the medicine we know. As part of this study, the main risk factors for cardiovascular disease were identified. These include the following indicators: IN THIS ARTICLE 1 Why do you need cardiovascular risk assessments? 2 SCORE Risk Chart (Systematic Coronary Risk Evaluation) 3 Framingham Risk Score 4 Reynolds Risk Score 5 ASCVD (Atherosclerotic Cardiovascular Disease) Risk Score 6 PROCAM Score (Prospective Cardiovascular Munster Study) 7 QRISK (QRESEARCH Cardiovascular Risk Algorithm) 8 The 65yo Patient’s CVD Risks 9 Effectiveness of Using CVD Risk Scoring RELATED ARTICLES Valuable information has also been obtained on the role of cholesterol, age, gender, and psychological problems. During this time, the risk assessment has changed and developed significantly. In this article, we will analyze what cardiovascular risk assessment means and what calculators are used now in medical practice. SCORE Risk Chart (Systematic Coronary Risk Evaluation) The European guidelines for cardiovascular disease (CVD) prevention recommend the use of modified SCORE risk charts. SCORE estimates the 10-year risk of fatal and non-fatal CVDs such as myocardial infarction, cerebrovascular disease, and congestive heart failure. The first Joint Working Group of European societies on coronary prevention used a simple risk chart. For their calculations, they considered the following categories: Then, the diagram became more complex in order to assess risks more accurately. So, in addition to total cholesterol, the ratio of cholesterol to HDL cholesterol was also taken into account in risk assessments. In addition, given the geographic variability in cardiovascular risk across Europe, two SCORE charts have been developed for countries with high and low CVD risk. Countries with low risk include countries such as Andorra, Austria, Belgium, Cyprus, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Israel, Italy, Luxembourg, Malta, Monaco, Netherlands, Norway, Portugal, San Marino , Slovenia, Spain, Sweden, Switzerland and the United Kingdom of Great Britain and Northern Ireland. Countries at high risk of CVD: Bosnia and Herzegovina, Croatia, Czech Republic, Estonia, Hungary, Lithuania, Montenegro, Morocco, Poland, Romania, Serbia, Slovakia, Tunisia and Turkey. And the group of countries with a very high risk (note that the diagrams may underestimate the risk in these countries) included such countries as: Albania, Algeria, Armenia, Azerbaijan, Belarus, Bulgaria, Egypt, Georgia, Kazakhstan, Kyrgyzstan, Latvia, North Macedonia , Moldova, Russian Federation, Syrian Arab Republic, Tajikistan, Turkmenistan, Ukraine and Uzbekistan. Due to this SCORE scale, the following cardiovascular diseases can be detected: stroke, myocardial infarction, pulmonary embolism, dissecting aortic aneurysm. Framingham Risk Score The Framingham Risk Scale (FRS) determines the presence of diseases such as angina pectoris, coronary heart disease, myocardial infarction, stroke. Like the SCORE scale, this system opens the door for making a forecast for the next 10 years. This scale was developed in North America. Thus, NCEP 4 recommends the Framingham Risk Score for cardiovascular risk assessment. You can also calculate it by yourself. The total risk on the Framingham scale is defined as: A value over 30% indicates a very high risk of cardiovascular disease. A 10-year risk estimate can be obtained as a percentage, which is then used to make decisions about disease prevention. This assessment is also evolving. For example, in 2009 CCS added additional risks to the Framingham risk scale. It included a family history of coronary heart disease in a first-line relative. It takes into account male first-degree relative younger than 55 years and female first-degree relative younger than 65 years old. For elderly patients, sensitive C-reactive protein results can also help to reclassify risks. Reynolds Risk Score If you are healthy and do not have diabetes, the Reynolds Risk Score is designed for your cardiovascular risk assessment. It may predict your risk of heart attack, stroke, or other serious heart diseases over the next 10 years. The risk calculation is designed for people aged 45 and over. The scale assesses the following risk factors: gender, age, systolic blood pressure, total and

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